Description

n-Biotinyl-3,6-Dioxaoctane-1,8-Diamine is a specialized biotin derivative featuring a hydrophilic polyethylene glycol (PEG) spacer arm. This molecular design is critical for enhancing solubility and reducing steric hindrance, making it a superior linker for bioconjugation and labeling applications. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require reliable, high-purity intermediates for developing targeted therapeutics, diagnostic probes, and affinity-based purification systems.

Application

• Bioconjugation Reagent: Acts as a key linker for attaching biotin to antibodies, proteins, peptides, and other biomolecules for use in immunoassays (ELISA, Western Blot) and diagnostic kits.
• Affinity Chromatography Ligand Synthesis: Used to functionalize solid supports (e.g., agarose, magnetic beads) for streptavidin/avidin-based purification of tagged biomolecules.
• Drug Delivery Systems: Serves as a component in the synthesis of biotinylated drug conjugates and targeted nanoparticle formulations, leveraging the high affinity of the biotin-streptavidin interaction.
• Molecular Probes and Imaging Agents: Incorporated into the synthesis of fluorescent, radioactive, or other reporter-tagged probes for cellular imaging and in vivo diagnostics.
• Surface Modification: Employed to create biotinylated surfaces on biosensors, microarrays, and other bioanalytical platforms to capture specific analytes.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions, cellular trafficking, and other biological processes through biotinylation strategies.

Basic Information

Product Name	n-Biotinyl-3,6-Dioxaoctane-1,8-Diamine
CAS No.	138529-46-1
Molecular Formula	C20H38N4O5S
Molecular Weight	446.60 g/mol
Synonyms	Biotin-PEG3-amine; Biotin-PEG3-NH2; Biotinamidohexanoyl-PEG3-amine; 6-((6-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)hexyl)amino)-6-oxohexyl)biotinamide; Biotin-XX-PEG3-amine; Biotin-PEG3-alkylamine; N-Biotinyl-3,6,9-trioxaundecane-1,11-diamine; EZ-Link™ Biotin-PEG3-Amine (trade name equivalent)
EINECS	Contact for details

Quality Control

Our n-Biotinyl-3,6-Dioxaoctane-1,8-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via mass spectrometry (MS) and infrared (IR) spectroscopy, to ensure it meets the high standards required for sensitive life science applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This compound is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.