Description

2-Chloro-3-Hydroxybenzotrifluoride is a versatile halogenated aromatic building block characterized by the presence of both chloro and hydroxy substituents on a trifluoromethylated benzene ring. This unique molecular structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules requiring specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer Modification: Incorporated as a monomer or additive to impart specific properties like chemical resistance or altered refractive index in specialty polymers.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized aryl groups.
• Research & Development: Utilized in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal and materials chemistry.

Basic Information

Product Name	2-Chloro-3-Hydroxybenzotrifluoride
CAS No.	138377-34-1
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	3-Hydroxy-2-chlorobenzotrifluoride; 2-Chloro-α,α,α-trifluoro-m-cresol; 2-Chloro-3-(trifluoromethyl)phenol; 2-Chloro-α,α,α-trifluoro-3-hydroxybenzene; 2-Chloro-3-trifluoromethylphenol; 2-Chloro-3-hydroxybenzene trifluoride; 2-Chloro-3-(trifluoromethyl)phenol; 138377-34-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Hydroxybenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets stringent specifications for use in sensitive applications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.