Description

Z-Gly-Gly-Gly-Osu CAS NO 138346-57-3 is a protected tripeptide derivative where the N-terminus is blocked by a benzyloxycarbonyl (Z) group and the C-terminus is activated as an N-hydroxysuccinimide (Osu) ester. This molecular design matters because it serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled elongation of peptide chains. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled, sequential addition of glycine residues to growing peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation: The activated ester facilitates the covalent attachment of the Gly-Gly-Gly sequence to other molecules, such as proteins, antibodies, or surfaces, for creating labeled probes or biomaterials.
• Biochemical Research: Employed as a model compound or spacer arm in the study of enzyme kinetics, protein-protein interactions, and structural biology.
• Combinatorial Chemistry: A valuable reagent in libraries for discovering new bioactive compounds and lead optimization.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	Z-Gly-Gly-Gly-Osu
CAS No.	138346-57-3
Molecular Formula	C19H23N4O8
Molecular Weight	435.41 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]glycylglycylglycine N-hydroxysuccinimide ester; Z-Gly-Gly-Gly-OSu; Z-GGG-OSu; N-Cbz-Gly-Gly-Gly-OSu; Cbz-Gly-Gly-Gly-OSu; Nα-Carbobenzoxy-glycyl-glycyl-glycine N-succinimidyl ester; Benzyl N-[2-[2-(2-[[(2,5-dioxopyrrolidin-1-yl)oxy]-oxomethyl]amino]ethanoylamino]ethanoyl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Gly-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.