Description

Alnespirone is a high-purity, synthetic organic compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents targeting central nervous system disorders. This compound is essential for research institutions, pharmaceutical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the creation of new neuropharmacological treatments. We supply Alnespirone CAS NO 138277-78-8 to the global market with a commitment to stringent quality control and reliable supply chain integrity.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of proprietary drug candidates.
• Neuroscience Research: Used in preclinical studies to investigate mechanisms of action related to serotonin receptor modulation.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Contract Manufacturing: Supplied to CDMOs for scale-up and production under current Good Manufacturing Practice (cGMP) guidelines.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical studies.

Basic Information

Product Name	Alnespirone
CAS No.	138277-78-8
Molecular Formula	C₁₉H₂₈N₂O₃
Molecular Weight	332.44 g/mol
Synonyms	Alnespirone; 138277-78-8; 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione; 8-[4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione; Spiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-; UNII-1V8K3L3K8S
EINECS	Contact for details

Quality Control

Our Alnespirone is manufactured under a quality management system designed to meet the exacting standards of the pharmaceutical industry. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile determination via techniques such as HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) documenting all test results against predefined specifications is provided with every shipment. We can support development with research-grade material through to cGMP-compliant production for clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.