Description

1-((1R,2S,3S)-2-Azido-3-Hydroxycyclopentyl)Pyrimidine-2,4(1H,3H)-Dione is a sophisticated chiral nucleoside analog building block of significant interest in advanced pharmaceutical research and development. Its unique stereochemistry and functional groups make it a valuable precursor for the synthesis of novel antiviral and anticancer agents. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research-scale synthesis of nucleoside analog prodrugs.
• Antiviral Drug Development: Serves as a critical building block for potential therapeutics targeting viral polymerases.
• Oncology Research: Used in the design and synthesis of experimental chemotherapeutic agents that mimic natural nucleosides.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation & Probe Synthesis: The azido group allows for site-specific modification via click chemistry for creating diagnostic probes or targeted drug conjugates.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-((1R,2S,3S)-2-Azido-3-Hydroxycyclopentyl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	138191-95-4
Molecular Formula	C9H11N5O3
Molecular Weight	237.22 g/mol
Synonyms	(1R,2S,3S)-2-Azido-3-hydroxycyclopentyl uracil; 2'-Azido-2',3'-dideoxyuridine derivative; 1-[(1R,2S,3S)-2-Azido-3-hydroxycyclopentyl]uracil; AZT-Uracil Cyclopentyl Analog; NSC 330770; Uracil, 1-[(1R,2S,3S)-2-azido-3-hydroxycyclopentyl]-; Cyclopentyl azido diol uracil
EINECS	Contact for details

Quality Control

Every batch of 1-((1R,2S,3S)-2-Azido-3-Hydroxycyclopentyl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.