Description

3-Maleimidopropionylarginylmonoiodotyrosine is a specialized, heterobifunctional crosslinking reagent designed for precise biomolecular conjugation. This compound is critical for researchers and developers requiring site-specific labeling and stable covalent linkages, particularly in sensitive biological systems. It is primarily utilized in the pharmaceutical and biotechnology sectors for advanced applications in drug discovery, diagnostics, and proteomics research.

Application

• Bioconjugation Reagent: For site-specific covalent coupling of peptides, proteins, or antibodies to other biomolecules, surfaces, or carriers.
• Antibody-Drug Conjugate (ADC) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies.
• Diagnostic Assay Development: For immobilizing capture antibodies or antigens onto sensor surfaces in ELISA, lateral flow, or biosensor platforms.
• Proteomics Research: Used in crosslinking mass spectrometry (XL-MS) to study protein-protein interactions and complex structures.
• Biomaterial Functionalization: For modifying polymers, nanoparticles, or hydrogels with bioactive peptides to create advanced biomaterials.
• Fluorescent Probe Synthesis: As a building block for creating targeted fluorescent labels for cellular imaging.

Basic Information

Product Name	3-Maleimidopropionylarginylmonoiodotyrosine
CAS No.	138191-82-9
Molecular Formula	C23H31IN6O7
Molecular Weight	630.44 g/mol
Synonyms	Maleimidopropionyl-Arg-Iodotyrosine; MAPIT; 3-Maleimidopropionic acid-Arg-Tyr(I) conjugate; N-(3-Maleimidopropionyl)-L-arginyl-L-3-iodotyrosine; Heterobifunctional Crosslinker MAPIT; L-Tyrosine, N2-[N2-(3-maleimidopropionyl)-L-arginyl]-3-iodo-; Iodotyrosine-containing Maleimide Crosslinker; Arg-Iodotyrosine Maleimide
EINECS	Contact for details

Quality Control

Our 3-Maleimidopropionylarginylmonoiodotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.