Description

Calcitonin Gene-Related Peptide (19-37), T-Butyl-Cys(18)- is a synthetic peptide fragment of the neuropeptide CGRP, modified with a tert-butyl protecting group on the cysteine residue at position 18. This specific modification is crucial for research applications requiring enhanced stability or specific reactivity during peptide synthesis and conjugation studies. It serves as a vital biochemical tool for neuroscientists and pharmaceutical researchers investigating the complex role of CGRP in vasodilation, migraine pathophysiology, and cardiovascular regulation. The compound, identified by CAS No. 137908-73-7, is essential for developing targeted therapeutic strategies and diagnostic assays.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies exploring the physiological and pathological roles of CGRP in the central and peripheral nervous systems.
• Migraine & Pain Research: Critical for in vitro and in vivo models to study CGRP receptor antagonism and the development of next-generation migraine therapeutics.
• Cardiovascular Research: Employed to investigate CGRP's potent vasodilatory effects and its implications for blood pressure regulation and vascular diseases.
• Peptide Chemistry & Conjugation: The T-Butyl-Cys(18) modification makes it a key intermediate for site-specific bioconjugation, labeling (e.g., with fluorophores or biotin), and structure-activity relationship (SAR) studies.
• Pharmaceutical Development: Serves as a precursor or analog in the design and screening of novel peptide-based drugs targeting CGRP pathways.
• Diagnostic Assay Development: Utilized as a calibrated antigen or hapten in the development of immunoassays (ELISA, RIA) for detecting CGRP levels in biological samples.

Basic Information

Item	Detail
Product Name	Calcitonin Gene-Related Peptide (19-37), T-Butyl-Cys(18)-
CAS No.	137908-73-7
Molecular Formula	C99H155N29O28S2
Molecular Weight	2208.6 g/mol
Synonyms	CGRP (19-37), T-Butyl-Cys(18)-; CGRP Fragment 19-37, [T-Butyl-Cys18]-; α-Calcitonin Gene-Related Peptide (19-37), [Tert-Butyl-Cys18]-; [T-Butyl-Cys18]-CGRP(19-37); Human CGRP-(19-37), [T-Butyl-Cys18]-; CGRP I (19-37), [T-Butyl-Cys18]-; Neuropeptide CGRP Fragment 19-37, Modified; T-Butyl-Cys18-CGRP(19-37)
EINECS	Contact for details

Quality Control

Our Calcitonin Gene-Related Peptide (19-37), T-Butyl-Cys(18)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for research and development. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, purity assessment, and batch-specific information upon request, supporting traceability and regulatory compliance for global clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values (±10%)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.