Description

Cyclo(-Arg-Ala-Asp-D-Phe-Val) is a synthetic, cyclic pentapeptide containing the Arg-Gly-Asp (RGD) motif, a sequence recognized by integrin receptors. This compound is a potent and selective antagonist of the αvβ3 and αvβ5 integrins, making it a critical research tool for studying cell adhesion, angiogenesis, and tumor metastasis. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, biochemical assay development, and as a reference standard. The product is supplied with CAS number 137813-36-6.

Application

• Integrin Research: A key tool for studying the biological functions and signaling pathways of αvβ3 and αvβ5 integrins in vitro and in vivo.
• Angiogenesis Inhibition Studies: Used to investigate and model the inhibition of new blood vessel formation, relevant to cancer and ocular disease research.
• Cell Adhesion & Migration Assays: Serves as a competitive inhibitor in assays designed to study cellular attachment, spreading, and motility on extracellular matrix proteins.
• Cancer Metastasis Research: Employed in preclinical studies to evaluate the role of integrins in tumor cell invasion and metastasis.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in peptide synthesis and characterization.
• Drug Discovery Scaffold: Provides a core structure for the design and development of novel therapeutic agents targeting integrin-mediated diseases.

Basic Information

Product Name	Cyclo(-Arg-Ala-Asp-D-Phe-Val)
CAS No.	137813-36-6
Molecular Formula	C27H41N9O7
Molecular Weight	603.68 g/mol
Synonyms	c(RGDfV); Cyclo(Arg-Ala-Asp-D-Phe-Val); Cilengitide (precursor/related compound); Cyclo(RGDfV); cRGDfV; Cyclopentapeptide RGDfV; Arg-Ala-Asp-D-Phe-Val cyclic peptide; αvβ3 Integrin Antagonist, Cyclic RGD Peptide
EINECS	Contact for details

Quality Control

Our Cyclo(-Arg-Ala-Asp-D-Phe-Val) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and chiral purity analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.