Description

Spiroglumide CAS NO 137795-35-8 is a selective and competitive antagonist of the metabotropic glutamate receptor subtype 1 (mGluR1). This compound is a valuable research tool for investigating glutamatergic signaling pathways in the central nervous system. It is primarily utilized by pharmaceutical researchers and neuroscientists in academic, biotechnology, and pharmaceutical development settings for target validation and preclinical studies.

Application

• Neuroscience Research: Fundamental studies on the role of mGluR1 receptors in synaptic transmission, plasticity, and neuronal excitability.
• Pharmacological Profiling: Used as a reference standard in in vitro and in vivo assays to characterize the selectivity and potency of new mGluR-targeting compounds.
• Target Validation: Critical for establishing the therapeutic potential of mGluR1 inhibition in various neurological and psychiatric disorder models.
• Drug Discovery & Development: A key biochemical tool in high-throughput screening (HTS) campaigns and lead optimization programs for CNS drug candidates.
• Academic Research: Investigating mechanisms underlying pain, anxiety, addiction, and neurodegenerative diseases where mGluR1 signaling is implicated.

Basic Information

Product Name	Spiroglumide
CAS No.	137795-35-8
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	(RS)-1-Amino-1,3-dicarboxycyclopentane; (RS)-ADCP; LY 344495; (1RS,3SR)-1-Aminocyclopentane-1,3-dicarboxylic Acid; Spiroglumide (LY344495); mGluR1 Antagonist LY344495; 1-Amino-1,3-cyclopentanedicarboxylic Acid
EINECS	Contact for details

Quality Control

Our Spiroglumide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.