Description

ω-Conotoxin Svia is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is of significant value in neuroscience research and pharmaceutical development due to its selective antagonism of N-type voltage-gated calcium channels (Cav2.2). It is primarily utilized by research institutions and biotechnology companies focused on studying pain pathways, neurological disorders, and developing novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for studying the role of N-type calcium channels in synaptic transmission, neuronal excitability, and neurotransmitter release.
• Pain Pathway Investigation: Used in preclinical models to investigate chronic pain mechanisms and validate Cav2.2 as a therapeutic target for analgesic development.
• Pharmacological Probe: Serves as a selective molecular probe to block Cav2.2 channels in electrophysiology, calcium imaging, and other functional assays.
• Drug Discovery & Development: Provides a structural and functional template for designing novel peptide-based or small-molecule drugs for neuropathic pain and other neurological conditions.
• Ion Channel Characterization: Essential for the functional characterization and subtype discrimination of voltage-gated calcium channels in recombinant cell systems.
• Biochemical Studies: Used in binding assays and studies of channel-protein interactions to understand complex signaling networks.

Basic Information

Product Name	ω-Conotoxin Svia
CAS No.	137706-81-1
Molecular Formula	C98H150N30O29S6
Molecular Weight	~ 2392.8 g/mol
Synonyms	ω-Conotoxin Svia; Conotoxin S VI A; ω-Conotoxin SVIA; SNX-325; ω-CTx Svia; N-type calcium channel blocker Svia; Ctx Svia
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Svia is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to rigorous in-house quality protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in aqueous buffers
Biological Activity (IC50)	Specified per batch (nM range)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.