Description

ω-Conotoxin Rvia, Conus Radiatus is a highly specific and potent peptide neurotoxin isolated from the venom of the marine cone snail, *Conus radiatus*. This compound is a critical research tool for studying N-type voltage-gated calcium channels (Cav2.2) in neuronal signaling and pain pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuroscience, ion channel pharmacology, and analgesic drug discovery programs.

Application

• Neuroscience Research: Selective blockade of N-type (Cav2.2) voltage-gated calcium channels to study synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Pathway Analysis: A key pharmacological tool for investigating the role of Cav2.2 channels in nociception and chronic pain models.
• Ion Channel Pharmacology: Used in electrophysiology (patch-clamp) and calcium imaging assays to characterize channel function and screen for novel modulators.
• Drug Discovery: Serves as a reference standard and lead compound in the development of new, non-opioid analgesic therapeutics targeting calcium channels.
• Biochemical Studies: Employed in receptor binding assays and structure-activity relationship (SAR) studies due to its high affinity and specificity.
• Academic & Pharmaceutical R&D: Essential reagent for basic research and preclinical development within university labs, CROs, and biopharma companies.

Basic Information

Product Name	ω-Conotoxin Rvia, Conus Radiatus
CAS No.	137688-17-6
Molecular Formula	C102H172N36O32S7
Molecular Weight	~2633.2 g/mol
Synonyms	ω-Conotoxin Rvia; Conotoxin Rvia; ω-Conotoxin R-VIA; Ctx Rvia; SNX-325; N-type Calcium Channel Blocker Rvia; Conus radiatus Toxin Rvia; ω-Ctx Rvia; Conopeptide Rvia
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Rvia is produced and purified under stringent conditions to ensure the highest standards of biological activity and batch-to-batch consistency. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and functional bioassays to verify potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and specific activity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Specific Activity	Verified by functional assay
Solubility	Soluble in aqueous buffers
Endotoxin Level	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.