Description

ω-Conotoxin Tvia is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is of significant value in neuroscience research and drug discovery due to its selective antagonism of N-type voltage-gated calcium channels (Cav2.2). It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of pain pathways, neurological disorders, and the development of novel analgesic therapeutics.

Application

• Neuroscience Research: As a selective pharmacological tool for blocking N-type calcium channels to study synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Research & Analgesic Development: Investigation of chronic pain mechanisms and as a reference compound for developing non-opioid pain medications targeting the Cav2.2 channel.
• Ion Channel Characterization: Used in electrophysiology (e.g., patch-clamp) and binding assays to characterize and subtype calcium channels in various cell lines and tissues.
• Pharmacological Standard: Serves as a high-purity reference standard in bioassay validation and quality control for related research products.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) campaigns to identify new molecules that modulate N-type calcium channel activity.
• Toxicology Studies: Research into the mechanism of action of conotoxins and their physiological effects.

Basic Information

Product Name	ω-Conotoxin Tvia
CAS No.	137688-12-1
Molecular Formula	C95H146N30O29S5
Molecular Weight	~2286.8 g/mol
Synonyms	ω-Conotoxin Tvia; Conotoxin Tvia; ω-CTx Tvia; GVIA; SNX-124; ω-CTx GVIA; N-type Calcium Channel Blocker Tvia; ω-Conotoxin from Conus geographus (Tvia variant)
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Tvia is produced and tested to meet the exacting standards required for advanced research. Each batch is subjected to rigorous analytical characterization to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) confirmation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	2286.8 ± 2.0 Da (by MS)
Biological Activity (IC50)	Specified per batch (typically low nM range vs. N-type Ca2+ channels)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers (e.g., PBS, saline) or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.