Description

Enkephalin, 2,6-Dimethyl-Tyr(1)-Pen(2,5)- is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, designed for enhanced receptor selectivity and metabolic stability. This compound is a critical research tool for investigating opioid receptor pharmacology, pain pathways, and neurobiological signaling. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, analgesic drug discovery, and peptide-based therapeutic development.

Application

• Neuroscience Research: A key ligand for studying delta (δ) and mu (μ) opioid receptor binding, activation, and downstream signaling cascades in vitro and in vivo.
• Analgesic Drug Discovery: Serves as a reference standard and lead compound in the development of novel, non-addictive pain management therapies with improved side-effect profiles.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional assays (e.g., cAMP inhibition, GTPγS binding) to characterize new chemical entities.
• Peptide Structure-Activity Relationship (SAR) Studies: The dimethyltyrosine and penicillamine modifications make it a valuable model for understanding how specific amino acid substitutions affect peptide stability, potency, and selectivity.
• Metabolic Stability Studies: Employed in pharmacokinetic research to evaluate the resistance of peptide analogs to enzymatic degradation.

Basic Information

Product Name	Enkephalin, 2,6-Dimethyl-Tyr(1)-Pen(2,5)-
CAS No.	137666-07-0
Molecular Formula	C34H48N6O7S2
Molecular Weight	716.91 g/mol
Synonyms	2,6-Dimethyl-Tyr1-Pen2,5-Enkephalin; [2,6-Dimethyl-Tyr1, D-Pen2,5]-Enkephalin; DADPE; Dmt-D-Pen2,5-Enkephalin; Dmt1-D-Pen2-D-Pen5-Enkephalin; Tyr(2,6-Me2)-D-Pen-Gly-Phe-D-Pen; Delta opioid receptor selective agonist; H-Tyr(2,6-diMe)-D-Pen-Gly-Phe-D-Pen-OH
EINECS	Contact for details

Quality Control

Our Enkephalin, 2,6-Dimethyl-Tyr(1)-Pen(2,5)- is manufactured under controlled conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.