Description

Axinastatin 1 is a potent, naturally-derived cyclic depsipeptide compound. It serves as a critical research-grade biochemical tool for studying cellular apoptosis and angiogenesis pathways. This high-purity compound is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on oncology and vascular biology.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of programmed cell death (apoptosis) and anti-angiogenic mechanisms.
• Pharmaceutical Development: Serves as a lead compound or molecular probe in the discovery and validation of novel anti-cancer therapeutics.
• Biochemical Assays: Employed in in vitro and cell-based assays to investigate signal transduction pathways related to tumor growth and metastasis.
• Academic Studies: Utilized in university and institutional laboratories for fundamental research in molecular biology and pharmacology.
• Quality Control: Acts as a certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	Axinastatin 1
CAS No.	137647-92-8
Molecular Formula	C34H49N7O9
Molecular Weight	699.80 g/mol
Synonyms	Axinastatin 1; Cyclo[(2S,3R)-3-hydroxy-2-methylpentanoyl-L-valyl-N-methyl-L-isoleucyl-L-threonyl-N-methyl-L-leucyl-L-phenylalanyl]; FR901228 (structural analog class); Depsipeptide FR-901228 derivative; NSC 630176; Antiangiogenic depsipeptide; Apoptosis-inducing cyclic peptide
EINECS	Contact for details

Quality Control

Our Axinastatin 1 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Assay-dependent; data available

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.