Description

L-Leucine, 2-(Hydroxymethyl)- is a specialized, non-proteinogenic amino acid derivative with a unique hydroxymethyl side chain. This structural modification imparts distinct chemical properties, making it a valuable chiral building block and intermediate for advanced synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for applications requiring high-purity, custom-tailored molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce modified leucine residues, altering peptide stability, solubility, or bioactivity.
• Bioconjugation & Probe Development: The hydroxymethyl group provides a handle for chemical conjugation, useful in creating fluorescent probes, antibody-drug conjugates (ADCs), or other bioconjugates for diagnostic and therapeutic research.
• Biochemical Research: Employed as a substrate analog or inhibitor in enzymatic studies to investigate amino acid metabolism and transport mechanisms.
• Fine Chemical Synthesis: Acts as a versatile intermediate for synthesizing more complex, high-value organic compounds in agrochemical and material science research.

Basic Information

Product Name	L-Leucine, 2-(Hydroxymethyl)-
CAS No.	137503-94-7
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	(2S)-2-Amino-4-methyl-5-hydroxy-1-pentanoic acid; 5-Hydroxy-L-leucine; L-5-Hydroxyleucine; (S)-2-Amino-5-hydroxy-4-methylpentanoic acid; Hyle; 2-(Hydroxymethyl)-L-leucine; 5-Hydroxy-L-leucine
EINECS	Contact for details

Quality Control

Our L-Leucine, 2-(Hydroxymethyl)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for research and synthesis. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.