Description

Substance P Acetate Salt Hydrate, Biochemika is a high-purity, biologically active peptide derivative of the neuropeptide Substance P. This compound is critical for research and development in neuroscience, pharmacology, and cell biology, serving as a potent and specific agonist for the neurokinin-1 (NK-1) receptor. It is an essential tool for scientists investigating pain signaling pathways, neurogenic inflammation, and the role of tachykinins in various physiological and pathological processes. The product is supplied as a lyophilized powder, ensuring stability and ease of reconstitution for experimental use.

Application

• Neuroscience Research: Used as a standard agonist to study the role of Substance P and NK-1 receptors in central and peripheral nervous system function, including pain transmission, stress responses, and emotional behavior.
• Pharmacological Assays: Employed in high-throughput screening (HTS) and in vitro binding assays to identify and characterize novel NK-1 receptor antagonists for drug discovery.
• Cell Signaling Studies: Applied to stimulate cells in culture to investigate intracellular signaling cascades, gene expression, and inflammatory mediator release triggered by NK-1 receptor activation.
• Inflammation Models: Used in preclinical research to induce neurogenic inflammation and study potential therapeutic interventions for conditions like migraine, arthritis, and inflammatory bowel disease.
• Biochemical Standard: Serves as a reference standard for the quantification and validation of Substance P in analytical methods such as HPLC, LC-MS, and ELISA.

Basic Information

Product Name	Substance P Acetate Salt Hydrate, Biochemika
CAS No.	137348-11-9
Molecular Formula	C63H98N18O13S • xC2H4O2 • yH2O
Molecular Weight	~1347.6 (for free peptide, variable with salt and hydrate form)
Synonyms	Substance P acetate; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt hydrate; Neurokinin P; SP; Tachykinin precursor 1 (100-111) amide; NK-1 Receptor Agonist; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate; SP (1-11)
EINECS	Contact for details

Quality Control

Our Substance P Acetate Salt Hydrate, Biochemika is manufactured under controlled conditions to ensure the highest standards of purity and biological activity. Each batch undergoes rigorous analytical testing, including reversed-phase HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, acetate counter-ion content, and residual solvent levels are available upon request to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area percent at 214 nm or 280 nm)
Peptide Content	≥ 70% (by AAA or quantitative NMR)
Acetate Content	~3-6 molar equivalents (by titration or IC)
Water Content (KF)	≤ 10.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO), acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.