Description

2-Chloro-5-Fluoro-6-Ethylpyrimidine is a high-purity, multi-functional halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecules with tailored biological and physical properties. It is primarily needed by pharmaceutical R&D teams and agrochemical manufacturers for developing new active ingredients, as well as by specialty chemical producers for creating advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Active Ingredient Development: Used in research to create new herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for metal catalysis and organocatalysts used in asymmetric synthesis.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic and Industrial R&D: Utilized in research laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-5-Fluoro-6-Ethylpyrimidine
CAS No.	137234-90-3
Molecular Formula	C6H6ClFN2
Molecular Weight	160.58 g/mol
Synonyms	2-Chloro-5-fluoro-6-ethylpyrimidine; 6-Ethyl-2-chloro-5-fluoropyrimidine; 5-Fluoro-2-chloro-6-ethylpyrimidine; 2-Chloro-5-fluoro-6-ethyl-1,3-diazine; Pyrimidine, 2-chloro-5-fluoro-6-ethyl-; 137234-90-3 (CAS); 2-Cl-5-F-6-Et-Pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-6-Ethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications from research to development scale, with the capability to supply material meeting specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.