Description

4-Ethyl-5-Fluoropyrimidine is a high-purity fluorinated pyrimidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms or pyrimidine scaffolds into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of novel drug candidates, especially in antiviral, anticancer, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluoropyrimidine moiety enhances biological activity and stability.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, functionalized polymers, and liquid crystals.
• Chemical Biology & Diagnostics: Employed in the synthesis of probes, tags, and molecular tools for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	4-Ethyl-5-Fluoropyrimidine
CAS No.	137234-88-9
Molecular Formula	C6H7FN2
Molecular Weight	126.13 g/mol
Synonyms	5-Fluoro-4-ethylpyrimidine; 4-Ethyl-5-fluoropyrimidine; 5-Fluoro-4-ethyl-1,3-diazine; Fluoropyrimidine derivative; Pyrimidine, 4-ethyl-5-fluoro-; 137234-88-9 (CAS); 4-Ethyl-5-fluoro-1,3-diazine
EINECS	Contact for details

Quality Control

Our 4-Ethyl-5-Fluoropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.