Description

4-Pyrimidineethanol, 6-Chloro-α-(2,4-Difluorophenyl)-5-Fluoro-β-Methyl-α-(1H-1,2,4-Triazol-1-Ylmethyl)-, (αr,βs)-Rel- CAS NO 137234-75-4 is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-functional heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antifungal and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potent antifungal agents and other specialized APIs.
• Antifungal Drug Development: A key structural component for triazole-based antifungal compounds, targeting fungal cytochrome P450 enzymes.
• Organic Synthesis Research: Used in academic and industrial R&D for exploring new chemical reactions and constructing complex molecular architectures.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for new drug candidates.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Pyrimidineethanol, 6-Chloro-α-(2,4-Difluorophenyl)-5-Fluoro-β-Methyl-α-(1H-1,2,4-Triazol-1-Ylmethyl)-, (αr,βs)-Rel-
CAS No.	137234-75-4
Molecular Formula	C16H13ClF3N5O
Molecular Weight	383.76 g/mol
Synonyms	rel-(αR,βS)-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (αR,βS)-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (rel); 6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (rel-(αR,βS)-); Intermediate for Antifungal APIs; Fluconazole-related intermediate; Triazole-pyrimidine derivative
EINECS	Contact for details

Quality Control

Our 4-Pyrimidineethanol intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D and scale-up. Each lot undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.