Description

4-Chloro-6-Ethyl-5-Fluoropyrimidine is a high-purity fluorinated pyrimidine building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside analogs and other bioactive molecules targeting viral and oncological diseases.
• Agrochemical Research: Used in the development of new generation herbicides and fungicides, leveraging its halogenated pyrimidine core.
• Chemical Synthesis: Serves as a versatile substrate for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution, enabling diverse molecular diversification.
• Material Science: Potential precursor for the synthesis of specialty polymers and liquid crystals due to its stable heterocyclic structure.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	4-Chloro-6-Ethyl-5-Fluoropyrimidine
CAS No.	137234-74-3
Molecular Formula	C6H6ClFN2
Molecular Weight	160.58 g/mol
Synonyms	5-Fluoro-4-chloro-6-ethylpyrimidine; 6-Ethyl-5-fluoro-4-chloropyrimidine; 4-Chloro-5-fluoro-6-ethylpyrimidine; 5-Fluoro-6-ethyl-4-chloropyrimidine; Pyrimidine, 4-chloro-6-ethyl-5-fluoro-; 137234-74-3; 4-Chloro-5-fluoro-6-ethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Ethyl-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound is moisture-sensitive; keep container tightly sealed under inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.