Description

Ac-Thr(Ac)-Oh CAS NO 137197-06-9 is a protected derivative of the amino acid threonine, specifically N-acetyl-O-acetyl-L-threonine. This compound is a crucial building block in peptide synthesis and pharmaceutical research, offering precise control over side-chain reactivity. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced organic synthesis. Its role is essential for constructing complex peptide sequences where selective deprotection strategies are required.

Application

• Peptide Synthesis: Serves as a key protected amino acid intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Used in the research and development of novel therapeutic peptides and protein-based drugs.
• Bioconjugation: Acts as a precursor for creating specialized linkers or modified amino acids in bioconjugation chemistry.
• Chemical Biology: Employed in studies investigating protein structure, function, and protein-protein interactions.
• Process Development: Utilized in scaling up and optimizing synthetic routes for peptide active pharmaceutical ingredients (APIs).
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in laboratories.

Basic Information

Product Name	Ac-Thr(Ac)-Oh CAS NO 137197-06-9
CAS No.	137197-06-9
Molecular Formula	C8H13NO5
Molecular Weight	203.19 g/mol
Synonyms	N-Acetyl-O-acetyl-L-threonine; O-Acetyl-N-acetyl-L-threonine; Ac-L-Thr(Ac)-OH; (2S,3R)-2-Acetamido-3-acetoxybutanoic acid; L-Threonine, N-acetyl-, acetate (ester); N-Acetylthreonine acetate; N-Acetyl-O-acetylthreonine; Protected L-Threonine derivative
EINECS	Contact for details

Quality Control

Our Ac-Thr(Ac)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent testing. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D = Specific range (Contact for details)
Chiral Purity	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.