Description

Tyr-Pdgf A-Chain (194-211) CAS NO 137132-69-5 is a synthetic peptide fragment corresponding to a specific region of the Platelet-Derived Growth Factor A-chain. This high-purity peptide is a critical research tool for studying cellular signaling pathways, receptor interactions, and the role of PDGF in processes like wound healing, angiogenesis, and fibrosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, cardiovascular disease, and tissue regeneration.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of PDGF receptor (PDGFR) binding, activation, and downstream signaling cascades.
• Cell Culture & Assay Development: Employed to stimulate cell proliferation, migration, and differentiation in various in vitro models, particularly for fibroblasts and smooth muscle cells.
• Drug Discovery & Screening: Serves as a target or competitor in high-throughput screening (HTS) assays to identify novel inhibitors or modulators of the PDGF pathway.
• Antibody Production & Characterization: Acts as a specific antigen for generating and testing antibodies against the PDGF A-chain epitope.
• Mechanistic Studies in Disease Models: Applied in research investigating the role of PDGF in atherosclerosis, cancer stroma formation, and organ fibrosis.
• Quality Control: Used as a system suitability standard in analytical methods for related biopharmaceutical products.

Basic Information

Product Name	Tyr-Pdgf A-Chain (194-211)
CAS No.	137132-69-5
Molecular Formula	C108H164N30O33
Molecular Weight	~2387.7 g/mol
Synonyms	PDGF A-Chain (194-211), Tyr-PDGF-AA (194-211); Platelet-Derived Growth Factor A Chain Peptide (194-211), tyrosine-modified; H-Tyr-Lys-Arg-Lys-Leu-Val-Glu-Lys-Ser-Gly-His-Val-Arg-Val-Arg-Leu-Arg-OH; PDGFA (194-211); PDGF-AA fragment; Synthetic PDGF A-chain peptide.
EINECS	Contact for details

Quality Control

Every batch of Tyr-Pdgf A-Chain (194-211) is manufactured under controlled conditions and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality system is designed to support research and development applications requiring high reliability. A detailed Certificate of Analysis (COA) providing results for purity (HPLC), molecular weight (MS), and peptide content is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For optimal performance, prepare aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Molecular Weight (MS)	Within ± 2 Da of theoretical
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.