Description

1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid is a high-purity pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of advanced fluoroquinolone antibiotic agents. It is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development and production of novel antibacterial therapeutics.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A vital precursor in the synthesis of potent antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new naphthyridine-based drug candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale production of active pharmaceutical ingredients for finished dosage forms.
• Process Chemistry & Optimization: Utilized in the development and scaling of efficient, cost-effective synthetic routes for complex molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical labs.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid
CAS No.	137118-01-5
Molecular Formula	C₁₂H₉FN₂O₃
Molecular Weight	248.21 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 6-Fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 6-Fluoro-1-cyclopropyl-4-oxo-1,8-naphthyridine-3-carboxylic acid; Fluoroquinolone intermediate 137118-01-5; CPFX acid intermediate
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical R&D and GMP manufacturing. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.