Description

Proparathyroid Hormone (-6-+84), Formylmethionyl- is a synthetic peptide fragment of the parathyroid hormone (PTH) precursor, specifically the proparathyroid hormone sequence. This high-purity biochemical is critical for advanced research into PTH biosynthesis, processing, and receptor interaction studies. It serves as an essential reference standard and active pharmaceutical ingredient (API) intermediate for researchers and developers in the fields of endocrinology, metabolic bone disease research, and peptide-based therapeutic development.

Application

• Biomedical Research: Used as a key reagent in studies of parathyroid hormone biosynthesis, secretion, and intracellular processing.
• Reference Standard: Serves as a high-purity analytical standard for HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Peptide Chemistry: Acts as a building block or intermediate in the custom synthesis of longer PTH-related peptide sequences for structure-activity relationship (SAR) studies.
• Drug Discovery: Utilized in screening assays and biological activity tests to evaluate compounds targeting the PTH/PTHrP receptor pathway for conditions like osteoporosis and hypoparathyroidism.
• Antibody Production: Employed as an immunogen for generating specific antibodies against proparathyroid hormone or its fragments for diagnostic assay development.

Basic Information

Product Name	Proparathyroid Hormone (-6-+84), Formylmethionyl-
CAS No.	137085-31-5
Molecular Formula	C454H723N133O134S2
Molecular Weight	~10231.8 g/mol
Synonyms	Formylmethionyl-Proparathyroid Hormone(-6-+84); fM-ProPTH(-6-+84); N-Formylmethionyl-Proparathyroid Hormone Fragment -6 to +84; Pro-PTH(-6-+84), N-formyl-Met-; PTH Precursor Peptide; Parathyroid Hormone Prohormone Fragment; CAS 137085-31-5
EINECS	Contact for details

Quality Control

Our Proparathyroid Hormone (-6-+84), Formylmethionyl- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, employing techniques such as HPLC and mass spectrometry for verification. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.