Description

L-Proline, 3-(2-Propenyl)-, trans- (9Ci) is a non-proteinogenic, proline-derived amino acid featuring an allyl side chain. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized in pharmaceutical research for the development of novel active ingredients and in the synthesis of complex peptides and peptidomimetics. This high-purity compound is essential for chemists and researchers in life sciences requiring specific stereochemistry and functional group handles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other biologically active molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the unique trans-3-allyl-L-proline moiety, modifying peptide conformation and biological activity.
• Chemical Biology & Proteomics: Serves as a building block for creating specialized amino acid analogs used in studying protein structure, function, and protein-protein interactions.
• Asymmetric Catalysis: Employed as a precursor or ligand in the design of chiral catalysts for enantioselective synthesis.
• Agrochemical Research: Potential intermediate in the synthesis of novel, biologically active compounds for crop protection.
• Academic & Industrial R&D: Fundamental research chemical in universities and corporate labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	L-Proline, 3-(2-Propenyl)-, trans- (9Ci)
CAS No.	136880-96-1
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(2S,3R)-3-Allylproline; trans-3-Allyl-L-proline; (2S,3R)-3-(2-Propen-1-yl)-L-proline; 3-Allyl-L-proline; L-Proline, 3-(2-propenyl)-, (2S,3R)-; (2S,3R)-3-(Prop-2-en-1-yl)proline; 3-(Allyl)-L-proline; 3-Allyl-(2S,3R)-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 3-(2-Propenyl)-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specific impurity profiles. We support compliance with relevant regulatory frameworks for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% de (trans isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.