Description

Cyclo-(S,S)-2-Mercaptobenzoate-Arginyl-Glycyl-Aspartyl-2-Mercaptoanilide CAS NO 136620-01-4 is a specialized, high-purity cyclic peptide derivative designed for advanced biochemical and pharmaceutical research. This compound is critical for studying and modulating integrin-mediated cell adhesion and signaling pathways due to its specific structural motifs. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, cardiovascular disease, and tissue engineering. Our supply ensures consistent quality and reliable availability for your most demanding discovery and development projects.

Application

• Integrin Research: Serves as a key biochemical tool for investigating αvβ3 and other RGD-dependent integrin receptors in cell biology studies.
• Drug Discovery: Used as a reference standard or a lead compound scaffold in the development of novel anti-angiogenic and anti-metastatic therapeutic agents.
• Bioconjugation & Probe Development: The mercapto groups provide handles for site-specific conjugation to fluorescent dyes, biotin, or other moieties to create targeted molecular probes.
• In Vitro Diagnostics (IVD): May be employed in the development of assay components for detecting specific cellular interactions or biomarkers.
• Biomaterials & Tissue Engineering: Investigated for coating surfaces to promote or inhibit specific cell adhesion in engineered tissues and medical devices.
• Signal Transduction Studies: Utilized to selectively block integrin signaling pathways to elucidate their role in various physiological and pathological processes.

Basic Information

Product Name	Cyclo-(S,S)-2-Mercaptobenzoate-Arginyl-Glycyl-Aspartyl-2-Mercaptoanilide
CAS No.	136620-01-4
Molecular Formula	C30H38N8O8S2
Molecular Weight	678.80 g/mol
Synonyms	c(RGDfK) Thioether; Cyclo(RGDfK) thioether derivative; Cyclo(Arg-Gly-Asp-D-Phe-Lys) thioether analog; c[RGDfK(SH)₂]; RGD Cyclic Peptide Thioether; Integrin αvβ3 antagonist thioether; Cyclic RGDfK mercapto derivative; 2-Mercaptobenzoic acid-cyclo(Arg-Gly-Asp-D-Phe-Lys)-2-mercaptoanilide conjugate
EINECS	Contact for details

Quality Control

Every batch of Cyclo-(S,S)-2-Mercaptobenzoate-Arginyl-Glycyl-Aspartyl-2-Mercaptoanilide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your research, including HPLC purity ≥95% (typical), identity confirmation by mass spectrometry (MS) and infrared (IR) spectroscopy, and precise quantification of residual solvents and moisture. Certificates of Analysis (COA) with full chromatographic and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.