Description

Fmoc-3-Nitro-L-Tyrosine CAS NO 136590-09-5 is a protected, ortho-substituted derivative of the amino acid L-tyrosine, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing a nitro-functionalized tyrosine residue into peptide chains, which can serve as a versatile precursor for further chemical modifications or as a spectroscopic probe. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of complex bioactive peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the controlled incorporation of modified tyrosine into peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, where the nitro group allows for subsequent reduction to an amine for conjugation or further derivatization.
• Chemical Biology & Proteomics: Employed to create site-specifically labeled peptides for studying protein-protein interactions, enzyme activity, and cellular localization.
• Material Science: Serves as a functional monomer for synthesizing novel peptidomimetic polymers and smart biomaterials with specific chemical handles.
• Antibody-Drug Conjugate (ADC) Development: The functional nitro group provides a pathway for attaching cytotoxic payloads or fluorescent tags to targeting peptides or proteins.

Basic Information

Product Name	Fmoc-3-Nitro-L-Tyrosine
CAS No.	136590-09-5
Molecular Formula	C24H20N2O7
Molecular Weight	448.43 g/mol
Synonyms	Fmoc-3-Nitro-L-tyrosine; Fmoc-Tyr(3-NO2)-OH; N-(9-Fluorenylmethoxycarbonyl)-3-nitro-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3-nitrophenyl)propanoic acid; 3-Nitro-L-tyrosine, N-Fmoc derivative; Fmoc-L-Tyrosine(3-NO2); Fmoc-3-Nitrotyrosine; N-α-Fmoc-3-nitro-L-tyrosine
EINECS	Contact for details

Quality Control

Our Fmoc-3-Nitro-L-Tyrosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	-10.0° to -14.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.