Description

Cyclo(Glutamyl-Prolyl-Valyl-Leucyl-Tryptophyl) CAS NO 136553-76-9 is a synthetic cyclic pentapeptide of significant interest in advanced biochemical research and development. This compound serves as a crucial building block and model system for studying peptide conformation, stability, and receptor interactions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on peptide-based therapeutics and diagnostic tools. Its defined cyclic structure offers unique insights into molecular recognition and bioactivity.

Application

• Pharmaceutical Research & Development: As a reference standard and intermediate in the discovery and synthesis of novel peptide-based drugs targeting various disease pathways.
• Biochemical Studies: For investigating peptide folding, conformational stability, and structure-activity relationships (SAR) in model systems.
• Enzyme Substrate/Inhibitor Studies: Used in enzymatic assays to study protease activity, specificity, and the development of enzyme inhibitors.
• Cell Signaling Research: As a tool compound to probe peptide-receptor interactions and intracellular signaling mechanisms.
• Academic & Contract Research: A key material for fundamental research in universities and CROs (Contract Research Organizations) specializing in peptide science.
• Peptide Library Synthesis: Serves as a sophisticated component in the construction of specialized peptide libraries for high-throughput screening.

Basic Information

Product Name	Cyclo(Glutamyl-Prolyl-Valyl-Leucyl-Tryptophyl)
CAS No.	136553-76-9
Molecular Formula	C33H45N7O7
Molecular Weight	651.76 g/mol
Synonyms	Cyclo(Glu-Pro-Val-Leu-Trp); c(Glu-Pro-Val-Leu-Trp); Cyclic Pentapeptide (Glu-Pro-Val-Leu-Trp); Cyclo(L-Glutamyl-L-prolyl-L-valyl-L-leucyl-L-tryptophyl); L-Glutamic acid, cyclic (1→5)-peptide with L-proline, L-valine, L-leucine and L-tryptophan; 136553-76-9; Cyclo(EPVLM) (using single-letter amino acid code: E-P-V-L-W)
EINECS	Contact for details

Quality Control

Our Cyclo(Glutamyl-Prolyl-Valyl-Leucyl-Tryptophyl) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can provide material tailored to specific project requirements, including research-grade and higher purity tiers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.