Description

Fmoc-L-Azetidine-2-Carboxylic Acid CAS NO 136552-16-4 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for introducing the conformationally constrained azetidine-2-carboxylic acid moiety into peptide chains, which is valuable for creating novel bioactive molecules with enhanced stability and specific pharmacological profiles. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in the development of peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Peptidomimetic Drug Discovery: Used to incorporate the rigid, four-membered azetidine ring to modulate peptide backbone conformation, improve metabolic stability, and explore structure-activity relationships (SAR).
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of constrained peptides for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the synthesis of peptide tags, linkers, and fluorescent probes for biochemical and cellular studies.
• Academic and Industrial Research: Fundamental reagent for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	Fmoc-L-Azetidine-2-Carboxylic Acid
CAS No.	136552-16-4
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	Fmoc-Aze-OH; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)azetidine-2-carboxylic acid; N-α-Fmoc-L-azetidine-2-carboxylic acid; Fmoc-L-2-azetidinecarboxylic acid; N-Fmoc-L-azetidine-2-carboxylic acid; Fmoc-Azetidine-2-COOH; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Azetidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to guarantee reproducible performance and supply chain traceability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.