Description

(S)-n-Fmoc-Azetidine-2-Carboxylic Acid CAS NO 136552-06-2 is a high-purity, non-proteinogenic amino acid derivative featuring an Fmoc-protected amine group and an azetidine ring. This compound is a critical chiral building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained ring structures to modulate biological activity and stability. It is essential for researchers and manufacturers in pharmaceutical development, particularly in creating novel drug candidates for metabolic diseases, oncology, and CNS disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and peptidomimetic drugs.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid building block for the automated synthesis of peptide chains containing the constrained azetidine moiety.
• Conformationally Restricted Peptide Design: Incorporates the four-membered azetidine ring to impose specific backbone conformations, enhancing peptide metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core structure in designing inhibitors that target specific proteolytic enzymes.
• Chemical Biology & Probe Development: Utilized in the synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular pathways.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting cutting-edge research in medicinal chemistry and peptide science.

Basic Information

Product Name	(S)-n-Fmoc-Azetidine-2-Carboxylic Acid
CAS No.	136552-06-2
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	Fmoc-Aze-OH; (S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic Acid; Fmoc-L-Azetidine-2-carboxylic Acid; (S)-N-Fmoc-2-Azetidinecarboxylic Acid; 1-Fmoc-azetidine-2-carboxylic acid; (S)-2-[(9-Fluorenylmethoxycarbonyl)amino]cyclobutanecarboxylic acid (related); Fmoc-Azetidine-2-COOH; Fmoc-Aze(2)-OH
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-Azetidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide a Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity. For long-term storage, consider storage at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.