Description

n-Fmoc-L-Threonine Allyl Ester is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound provides orthogonal protection, allowing for the selective deprotection of the allyl ester group while preserving the Fmoc group on the α-amino function, a critical strategy for constructing complex peptides. It is a vital building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptide chains using Fmoc/allyl orthogonal protection strategies.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of peptide drugs, hormones, and other bioactive peptides.
• Bioconjugation and Labeling: Used to introduce threonine residues with a protected side-chain and a selectively removable carboxyl group for site-specific modifications.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening purposes.
• Glycopeptide Synthesis: The allyl ester protection is particularly useful for synthesizing glycopeptides, where the carbohydrate moiety must be introduced at a later stage.
• Research & Development: An essential reagent in academic and industrial R&D labs focused on peptide science and medicinal chemistry.

Basic Information

Product Name	n-Fmoc-L-Threonine Allyl Ester
CAS No.	136523-92-7
Molecular Formula	C₂₂H₂₃NO₆
Molecular Weight	397.42 g/mol
Synonyms	Fmoc-Thr(All)-OH; Fmoc-L-threonine allyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine allyl ester; Allyl O-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxybutanoate]; (2S,3R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxybutyric acid allyl ester; Fmoc-Thr(All); N-Fmoc-O-allyl-L-threonine
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Threonine Allyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP-related applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.