Description

2-Cyclopentene-1-Methanol, 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- is a high-purity, stereochemically defined nucleoside analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block for the development of novel antiviral and anticancer therapeutics, where precise molecular configuration is paramount for biological activity. It is primarily required by research institutions, custom synthesis laboratories, and pharmaceutical companies engaged in the development of next-generation nucleoside-based Active Pharmaceutical Ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Development: Used in the synthesis of experimental compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents designed to disrupt DNA synthesis in cancer cells.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the scale-up of proprietary drug candidates.
• Biochemical Research: Utilized in academic and industrial labs to study enzyme-substrate interactions and nucleoside metabolism.
• Process Chemistry: Integral to route scouting and optimization for the efficient, scalable synthesis of complex nucleoside derivatives.

Basic Information

Product Name	2-Cyclopentene-1-Methanol, 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
CAS No.	136470-79-6
Molecular Formula	C14H18N6O
Molecular Weight	286.33 g/mol
Synonyms	(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; Carbocyclic Nucleoside Intermediate; Cyclopropylaminopurine Cyclopentenylmethanol Derivative; Abacavir Intermediate Analog; (1R,4S)-2-Cyclopenten-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-; cis-4-[2-Amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-enylmethanol
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality systems to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.