Description

n-Formylmethionyl-Dipropylglycyl-Phenylalanine Methyl Ester CAS NO 136427-57-1 is a synthetic peptide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial building block and a model substrate for studying enzyme kinetics, particularly for proteases and peptidases. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, metabolic pathway analysis, and the development of novel therapeutic agents. Its defined structure makes it an essential tool for high-precision biochemical assays and mechanistic studies.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and screening of novel peptide-based drugs and enzyme inhibitors.
• Biochemical Assays: Used as a specific substrate for characterizing the activity, specificity, and inhibition profiles of proteolytic enzymes like chymotrypsin, elastase, and other serine proteases.
• Metabolic Studies: Employed in research to investigate peptide metabolism, degradation pathways, and cellular uptake mechanisms.
• Academic Research: A valuable tool in university and institutional labs for teaching and advanced research in biochemistry, enzymology, and medicinal chemistry.
• Process Development: Serves as a model compound for optimizing synthetic peptide manufacturing and purification processes in a GMP environment.

Basic Information

Product Name	n-Formylmethionyl-Dipropylglycyl-Phenylalanine Methyl Ester
CAS No.	136427-57-1
Molecular Formula	C24H35N3O6S
Molecular Weight	493.62 g/mol
Synonyms	N-Formyl-Met-Dipropylgly-Phe-OMe; Formyl-Met-Dpg-Phe-OMe; F-Met-Dpg-Phe-OMe; N-Formylmethionyl-α-amino-α-methylbutyryl-phenylalanine methyl ester; (S)-Methyl 2-((S)-2-((S)-2-formamido-4-(methylthio)butanamido)-2-methylpentanamido)-3-phenylpropanoate; Peptide Substrate for Elastase/Chymotrypsin; Model Protease Substrate
EINECS	Contact for details

Quality Control

Our n-Formylmethionyl-Dipropylglycyl-Phenylalanine Methyl Ester is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.