Description

Boc-D-Pentafluorophenylalanine is a high-purity, non-natural amino acid derivative extensively used in advanced peptide synthesis. This compound is critical for introducing the unique physicochemical properties of the pentafluorophenyl group into peptide backbones, enhancing stability and enabling specific molecular interactions. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic researchers developing novel therapeutic peptides, diagnostic agents, and specialized biochemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of therapeutic peptides targeting metabolic and neurological disorders.
• Peptide-Based Drug Discovery: Used to incorporate fluorinated aromatic side chains to modulate peptide lipophilicity, metabolic stability, and receptor binding affinity.
• Positron Emission Tomography (PET) Tracer Development: Serves as a precursor for synthesizing fluorinated amino acid analogs used as radiotracers in medical imaging.
• Bioconjugation & Labeling Reagents: Employed in the creation of cross-linking agents and fluorescent probes for biochemical and cellular studies.
• Material Science Research: Used to engineer fluorinated peptides for creating novel bio-inspired materials and surfaces.
• Academic & Contract Research: A fundamental reagent for studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR) in non-natural peptide systems.

Basic Information

Product Name	Boc-D-Pentafluorophenylalanine
CAS No.	136207-26-6
Molecular Formula	C20H16F5NO4
Molecular Weight	429.34 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-pentafluorophenylalanine; Boc-D-Phe(2,3,4,5,6-F5)-OH; tert-Butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(pentafluorophenyl)propanoate; Boc-D-Phe(F5)-OH; N-Boc-D-pentafluorophenylalanine; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(pentafluorophenyl)propanoic acid; D-2-Amino-3-(pentafluorophenyl)propionic acid N-Boc derivative
EINECS	Contact for details

Quality Control

Our Boc-D-Pentafluorophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.