Description

3-Mercaptopropionyl-β-3-Pyridyl-D-Ala-Phe-Gln-Asn-Cys-Pro-Arg-Gly-Nh2 is a synthetic, modified peptide sequence of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key intermediate or active pharmaceutical ingredient (API) in the creation of novel therapeutic agents, particularly those targeting specific biological pathways. Research organizations and pharmaceutical manufacturers require this high-purity peptide for applications in drug discovery, preclinical studies, and the development of targeted biologics. Its specific structure, incorporating a mercaptopropionyl group and a β-3-pyridyl-alanine residue, makes it a valuable tool for conjugation and stability studies.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis of novel peptide-based therapeutics and drug candidates.
• Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to identify and optimize new bioactive molecules.
• Bioconjugation & Labeling: The mercapto (-SH) group enables site-specific conjugation with other molecules, such as fluorophores, polymers, or drug delivery vehicles.
• Enzyme & Receptor Studies: Acts as a substrate, inhibitor, or ligand in biochemical assays to study enzyme kinetics and receptor-ligand interactions.
• Preclinical & Clinical Trial Material: Manufactured under controlled conditions to supply material for non-clinical safety assessments and early-phase clinical studies.
• Peptide Library Synthesis: Used as a building block in combinatorial chemistry for generating diverse peptide libraries.

Basic Information

Product Name	3-Mercaptopropionyl-β-3-Pyridyl-D-Ala-Phe-Gln-Asn-Cys-Pro-Arg-Gly-Nh2
CAS No.	136105-89-0
Molecular Formula	C52H75N17O14S2
Molecular Weight	1194.4 g/mol
Synonyms	3-Mercaptopropionyl-β-(3-Pyridyl)-D-Ala-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2; S-(3-Mercaptopropionyl)-β-(3-pyridyl)-D-alanyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide; Modified Peptide 136105-89-0; β-(3-Pyridyl)-D-Alanine containing peptide; Thiol-functionalized peptide; Peptide-drug conjugate intermediate; API Intermediate 136105-89-0
EINECS	Contact for details

Quality Control

This peptide is manufactured under strict cGMP (current Good Manufacturing Practice) guidelines to ensure the highest standards of purity and consistency required for pharmaceutical applications. Our products undergo rigorous quality testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Comprehensive Certificates of Analysis (COA) detailing identity, purity (typically ≥95% to ≥98%), and impurity profiles are available upon request to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be stored under desiccant. It is also easily oxidized (store under inert atmosphere). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.