Description

Fmoc-Dl-Serine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its primary value lies in the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is selectively removable under mild basic conditions, enabling the controlled, sequential construction of complex peptides. This compound is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools. The DL- (racemic) form provides versatility for specific research applications where the stereochemistry is not constrained.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the Fmoc-strategy synthesis of custom peptides and peptide libraries.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug candidates.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carrier proteins in bioconjugate chemistry.
• Combinatorial Chemistry: A key reagent for generating diverse compound libraries for high-throughput screening in drug discovery programs.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR) of peptides.
• Material Science: Can be incorporated into peptide-based polymers or hydrogels for advanced biomaterials.

Basic Information

Item	Details
Product Name	Fmoc-Dl-Serine
CAS No.	136083-72-2
Molecular Formula	C18H17NO6
Molecular Weight	343.33 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-serine; Fmoc-Ser-OH; Fmoc-DL-serine; 9-Fluorenylmethyloxycarbonyl-DL-serine; N-Fmoc-DL-serine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic acid; DL-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, chiral purity, and residual solvent levels.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.