Description

Fmoc-D-Asp-Oh CAS NO 136083-57-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of D-aspartic acid into peptide chains, enabling the creation of complex, non-natural peptides with enhanced stability and biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing novel therapeutic peptides, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated, sequential assembly of custom peptides, particularly those requiring D-amino acids for metabolic stability.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, hormone analogs, and enzyme inhibitors where D-aspartic acid is incorporated to modulate bioavailability and receptor interaction.
• Bioconjugation & Probe Development: Used in the preparation of labeled peptides for imaging, diagnostic assays, and targeted drug delivery systems.
• Academic & Biochemical Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and the exploration of novel peptide architectures.
• Production of Protected Peptide Fragments: For use in fragment condensation strategies to synthesize long or challenging peptide sequences.

Basic Information

Item	Detail
Product Name	Fmoc-D-Asp-Oh
CAS No.	136083-57-3
Molecular Formula	C19H17NO6
Molecular Weight	355.34 g/mol
Synonyms	Fmoc-D-aspartic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic acid; Fmoc-D-Asp-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)butanedioic acid; D-2-[(Fmoc)amino]succinic acid; Fmoc-D-Aspartic Acid; N-Fmoc-D-aspartic acid; Fmoc-D-Asp(OtBu)-OH precursor (free acid form)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asp-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.