Description

Fmoc-Cys(4-Mbzl)-Oh is a protected cysteine derivative, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled and sequential assembly of peptides, particularly those requiring the selective deprotection and functionalization of cysteine residues. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated or manual synthesis of complex peptides and proteins.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases, where cysteine is crucial for disulfide bridge formation and structural stability.
• Bioconjugation and Labeling: The protected thiol group allows for site-specific modification, enabling the attachment of fluorescent dyes, biotin, polymers, or other functional moieties to peptides.
• Chemical Biology Research: Employed in the study of protein-protein interactions, enzyme mechanisms, and the development of peptide mimetics and inhibitors.
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as an intermediate in constructing linker-payload systems for targeted cancer therapies.
• Material Science: Used to create peptide-based biomaterials, hydrogels, and surface coatings where controlled cysteine incorporation is required.

Basic Information

Product Name	Fmoc-Cys(4-Mbzl)-Oh
CAS No.	136050-67-4
Molecular Formula	C26H23NO4S
Molecular Weight	445.53 g/mol
Synonyms	Fmoc-Cys(4-MBzl)-OH; Fmoc-S-(4-methylbenzyl)-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methylphenyl)methyl]-L-cysteine; Fmoc-Cys(Mob)-OH; Fmoc-L-Cys(4-Me-Bzl)-OH; Nα-Fmoc-S-(4-methylbenzyl)-L-cysteine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((4-methylbenzyl)thio)propanoic acid; Fmoc-Cysteine(4-methylbenzyl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(4-Mbzl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and reliability for your research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.