Description

Fmoc-Ser(Tbu)-Aib-Oh is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) into peptide sequences, which is critical for modifying peptide conformation and stability. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research laboratories focused on developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of complex peptides using Fmoc-chemistry protocols.
• Peptidomimetic Drug Development: Incorporation of the Aib residue to induce specific helical conformations, enhance metabolic stability, and improve bioavailability of peptide-based drug candidates.
• Antimicrobial Peptide (AMP) Research: Used in the synthesis of novel AMPs where structural rigidity from Aib can influence membrane interaction and potency.
• Hormone Analog Synthesis: Building block for creating analogs of peptide hormones (e.g., GLP-1, somatostatin) with improved pharmacological profiles.
• Bioconjugation and Probe Synthesis: Serves as a starting material for creating labeled or functionalized peptides for diagnostic and imaging applications.
• Academic & Process Chemistry: Used in methodological studies and for the scale-up synthesis of target peptide sequences under GMP-like conditions.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Aib-Oh
CAS No.	135875-33-1
Molecular Formula	C27H34N2O6
Molecular Weight	482.57 g/mol
Synonyms	Fmoc-Ser(t-But)-Aib-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-seryl-2-aminoisobutyric acid; Fmoc-Ser(O-t-Bu)-Aib-OH; Fmoc-L-Ser(tBu)-Aib-OH; Fmoc-Ser(Tert-butyl)-Aib-OH; Fmoc-Ser(O-tert-butyl)-2-aminoisobutyric acid; (2R)-2-[[(2S)-3-[(2-methylpropan-2-yl)oxy]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]propanoyl]amino]-2-methylpropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Aib-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements or regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0% (on anhydrous basis)
Specific Rotation	-15.0° to -19.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.