Description

n-α-(9-Fluorenylmethyloxycarbonyl)-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Argininepentafluorphenylester is a sophisticated, highly reactive amino acid derivative designed for advanced peptide synthesis. This compound matters because it serves as a critical building block, enabling the precise and efficient incorporation of protected arginine residues into complex peptide chains. Pharmaceutical researchers and fine chemical manufacturers need this high-purity reagent for developing therapeutic peptides, APIs, and other bioactive molecules where sequence fidelity is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled coupling of Fmoc-Arg(Mtr)-OH in automated and manual peptide synthesizers.
• Pharmaceutical Intermediate Production: A key raw material in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs) for therapeutic applications.
• Research & Development: Used in academic and industrial R&D labs for constructing model peptides, peptidomimetics, and investigating structure-activity relationships.
• Bioconjugation: Employed in the site-specific modification of proteins or other biomolecules by introducing arginine-containing peptide tags or linkers.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new lead compounds with biological activity.

Basic Information

Product Name	n-α-(9-Fluorenylmethyloxycarbonyl)-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Argininepentafluorphenylester
CAS No.	135793-01-0
Molecular Formula	C38H36F5N5O9S
Molecular Weight	833.78 g/mol
Synonyms	Fmoc-Arg(Mtr)-OPfp; Fmoc-L-arginine(Mtr)-pentafluorophenyl ester; Fmoc-Arg(Mtr)-OPfp ester; N-α-Fmoc-N-δ-(4-Methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine pentafluorophenyl ester; Fmoc-Arg(Mtr)-OPfp-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-5-((4-methoxy-2,3,6-trimethylphenyl)sulfonamido)pentanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Arg(Mtr)-OPfp Ester; Fmoc-Arg(Mtr)-OPfp
EINECS	Contact for details

Quality Control

Our n-α-(9-Fluorenylmethyloxycarbonyl)-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Argininepentafluorphenylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.