Description

Ac-Pen-Arg-Gly-Asp-Cys-Oh is a synthetic, linear peptide sequence containing the Arg-Gly-Asp (RGD) motif, a critical recognition site for integrin receptors. This compound is of significant value in biochemical research and pharmaceutical development due to its role in modulating cell adhesion and signaling pathways. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, drug discovery, and biomaterials engineering, where precise molecular interactions are studied and utilized.

Application

• Bioconjugation and Probe Development: Used as a targeting ligand for attaching fluorophores, nanoparticles, or drugs to specific cell types expressing integrins.
• Cell Adhesion Studies: Serves as a key reagent for investigating integrin-mediated cell attachment, spreading, and migration in vitro.
• Biomaterial Functionalization: Applied to coat surfaces of medical implants, scaffolds, and diagnostic devices to promote specific cellular interactions.
• Pharmaceutical Research: Acts as a lead compound or a structural component in the development of novel therapeutics targeting angiogenesis, thrombosis, or tumor metastasis.
• Diagnostic Assays: Utilized in the development of assays to detect or quantify integrin expression and activity.
• Inhibitor Studies: Functions as a competitive inhibitor to study the blockade of natural RGD-integrin binding events.

Basic Information

Product Name	Ac-Pen-Arg-Gly-Asp-Cys-Oh
CAS No.	135702-36-2
Molecular Formula	C24H39N11O9S2
Molecular Weight	689.78 g/mol
Synonyms	Acetyl-Pen-Arg-Gly-Asp-Cys-OH; Ac-Pen-RGD-Cys-OH; N-Acetyl-L-penicillamine-arginyl-glycyl-aspartyl-cysteine; Cyclic(RGDfC) precursor; RGD Peptide (acetylated, linear); Ac-CRGD-C; Ac-Cys-Arg-Gly-Asp-Cys-OH (cyclic disulfide bridge precursor); Integrin-binding peptide sequence
EINECS	Contact for details

Quality Control

Our Ac-Pen-Arg-Gly-Asp-Cys-Oh is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be stored under desiccant. For long-term storage, keep under an inert atmosphere to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.