Description

H-Pen(Trt)-Oh is a protected amino acid derivative, specifically Fmoc-L-Penicillamine(Trt)-OH, widely used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection of the thiol and amino groups, allowing for the controlled introduction of penicillamine into complex peptide sequences. This compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing therapeutic peptides and studying protein structure-function relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical Fmoc-protected amino acid for the automated synthesis of peptides containing penicillamine residues.
• Pharmaceutical Intermediate: Serves as a key precursor in the development of novel peptide-based drugs and bioactive compounds.
• Research & Development: Used in academic and industrial labs for studying disulfide bond formation, protein folding, and metal chelation in peptides.
• Bioconjugation Chemistry: The protected thiol group allows for site-specific modifications and labeling of peptides and proteins.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.

Basic Information

Product Name	H-Pen(Trt)-Oh
CAS No.	135681-66-2
Molecular Formula	C31H29NO3S
Molecular Weight	495.63 g/mol
Synonyms	Fmoc-L-Penicillamine(Trt)-OH; Fmoc-Pen(Trt)-OH; N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-penicillamine; N-α-Fmoc-S-trityl-L-penicillamine; Fmoc-S-trityl-L-penicillamine; Fmoc-Pen(Trt)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methyl-3-(tritylsulfanyl)butanoic acid; Fmoc-Pen(StBu)-OH (related, but different protecting group)
EINECS	Contact for details

Quality Control

Our H-Pen(Trt)-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.