Description

Fmoc-Cha-Oh CAS NO 135673-97-1 is a protected amino acid derivative where the cyclohexylalanine (Cha) side chain is coupled with the fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise synthesis of custom peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based drugs, including hormone analogs and antimicrobial peptides.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: A key reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Employed in biochemical studies to investigate protein-protein interactions and enzyme mechanisms.
• Production of Cyclohexylalanine-Containing Peptides: Specifically incorporates the hydrophobic, conformationally restricted Cha residue to influence peptide stability and bioactivity.

Basic Information

Product Name	Fmoc-Cha-Oh
CAS No.	135673-97-1
Molecular Formula	C25H29NO4
Molecular Weight	407.50 g/mol
Synonyms	Fmoc-L-cyclohexylalanine; Fmoc-Cyclohexylalanine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-cyclohexylalanine; Fmoc-Cha-OH; Nα-Fmoc-L-cyclohexylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-cyclohexylpropanoic acid; Fmoc-L-2-amino-3-cyclohexylpropionic acid; N-Fmoc-cyclohexylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-Cha-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research and cGMP-grade requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.