Description

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-Oh is a synthetic peptide derivative, specifically a dinitrophenyl (Dnp)-labeled peptide sequence. This compound is a valuable biochemical tool used in proteomics research and enzyme activity studies, particularly as a substrate or inhibitor for proteolytic enzymes. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, well-characterized peptides for assay development and mechanistic studies.

Application

• Protease/Enzyme Substrate: Used as a chromogenic or fluorogenic substrate to study the activity, kinetics, and inhibition of specific proteases like trypsin or related serine proteases.
• Biochemical Research: Serves as a critical reagent in academic and industrial research for investigating protein-protein interactions, signal transduction pathways, and peptide metabolism.
• Pharmaceutical Development: Employed in drug discovery programs for screening and characterizing potential therapeutic enzyme inhibitors.
• Diagnostic Assay Development: Utilized in the design and validation of in vitro diagnostic (IVD) kits that measure specific enzymatic activity in clinical samples.
• Peptide Chemistry Reference Standard: Acts as a high-purity reference material for analytical method development (HPLC, MS) and quality control in peptide synthesis.

Basic Information

Product Name	Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-Oh
CAS No.	135662-07-6
Molecular Formula	C48H66N14O13S
Molecular Weight	1063.2 g/mol
Synonyms	Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg; Dnp-PLGMWSR-OH; N-2,4-Dinitrophenyl-Prolyl-Leucyl-Glycyl-Methionyl-Tryptophyl-Seryl-Arginine; 2,4-DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg; Dinitrophenyl Octapeptide; Dnp-Octapeptide; Protease Substrate Peptide Dnp-PLGMWSR; (2,4-Dinitrophenyl)-L-prolyl-L-leucylglycyl-L-methionyl-L-tryptophyl-L-seryl-L-arginine
EINECS	Contact for details

Quality Control

Our Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.