Description

4-Bromomethyl-2-Methylthiopyrimidine is a versatile and high-value brominated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its reactive bromomethyl group, which facilitates efficient alkylation and functionalization reactions, enabling the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, especially those containing pyrimidine cores, such as kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require a functionalized pyrimidine moiety.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and specialty polymers.
• Chemical Biology & Proteomics: Acts as a versatile linker or tagging reagent for bioconjugation and probe development due to its reactive halogen site.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Bromomethyl-2-Methylthiopyrimidine
CAS No.	135645-63-5
Molecular Formula	C6H7BrN2S
Molecular Weight	219.10 g/mol
Synonyms	2-Methylthio-4-(bromomethyl)pyrimidine; 4-(Bromomethyl)-2-(methylthio)pyrimidine; 2-(Methylsulfanyl)-4-(bromomethyl)pyrimidine; Pyrimidine, 4-(bromomethyl)-2-(methylthio)-; 4-Bromo-2-methylthiopyrimidine (common misnomer); 4-Bromomethyl-2-methylmercaptopyrimidine; 2-Methylmercapto-4-bromomethylpyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromomethyl-2-Methylthiopyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.