Description

2,5-Dichloro-3-(Glutathionyl-S-Yl)-1,4-Benzoquinone is a specialized biochemical reagent that functions as a potent and selective inhibitor of mitochondrial complex I (NADH:ubiquinone oxidoreductase). This compound matters for researchers and developers because it provides a critical tool for probing cellular respiration, studying reactive oxygen species (ROS) generation, and investigating the role of mitochondrial dysfunction in disease pathways. Professionals in pharmaceutical R&D, academic biochemistry, and toxicology need this high-purity compound for mechanistic studies and as a reference standard.

Application

• Mitochondrial Research: A key tool for studying electron transport chain function, specifically for inhibiting and characterizing complex I activity.
• Biochemical Assay Development: Used as a reference standard and active agent in assays designed to measure mitochondrial respiration and oxidative stress.
• Neurodegenerative Disease Modeling: Employed in research models to induce mitochondrial dysfunction relevant to studying Parkinson's disease, Alzheimer's disease, and other neurological conditions.
• Cardiotoxicity & Hepatotoxicity Studies: Applied in preclinical safety assessment to investigate drug-induced organ toxicity mediated by mitochondrial impairment.
• Cancer Metabolism Research: Used to explore the metabolic vulnerabilities of cancer cells and the role of oxidative phosphorylation in tumor biology.
• ROS Generation Studies: Facilitates research into the mechanisms of reactive oxygen species production at the mitochondrial level.

Basic Information

Product Name	2,5-Dichloro-3-(Glutathionyl-S-Yl)-1,4-Benzoquinone
CAS No.	135608-87-6
Molecular Formula	C16H16Cl2N3O8S
Molecular Weight	481.29 g/mol
Synonyms	2,5-Dichloro-3-(S-glutathionyl)-1,4-benzoquinone; Glutathionyl-2,5-dichloro-1,4-benzoquinone; GDClBQ; Complex I Inhibitor (Glutathionyl-DCBQ); 1,4-Benzoquinone, 2,5-dichloro-3-[(2S)-1-[(2S)-2-amino-1-hydroxy-5-(1-hydroxy-3-sulfanyl-1-oxopropan-2-yl)amino]-1,5-dioxopentan-2-yl]amino]-3-sulfanylpropyl]sulfanyl]-; DCBQ-GSH Adduct
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-3-(Glutathionyl-S-Yl)-1,4-Benzoquinone is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and structural confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.