Description

Boc-D-Pen(Trt)-Oh is a protected, non-proteinogenic amino acid derivative widely used as a critical building block in peptide synthesis. This compound matters for its role in introducing the unique structural and functional properties of penicillamine into synthetic peptides and peptidomimetics under controlled conditions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, enzyme inhibitors, and novel drug candidates, where precise stereochemistry and side-chain protection are essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-penicillamine into peptide chains.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, enzyme inhibitors, and receptor ligands targeting various diseases.
• Bioconjugation & Probe Development: Used to create functionalized peptides for labeling, imaging, or diagnostic applications.
• Material Science: Building block for constructing peptidomimetic polymers and self-assembling biomaterials with specific chiral properties.
• Chemical Biology Studies: Tool for investigating protein-protein interactions and enzyme mechanisms through synthetic peptide analogs.

Basic Information

Product Name	Boc-D-Pen(Trt)-Oh
CAS No.	135592-14-2
Molecular Formula	C29H33NO4S
Molecular Weight	491.64 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-penicillamine trityl ether; Boc-D-penicillamine(Trt)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethyl-4-(tritylthio)butanoic acid; Boc-D-Pen(Trt)-OH; Boc-D-Pen(Trt); tert-Butyl (R)-1-((carboxy)-3,3-dimethyl-2-((tritylthio)methyl)propyl)carbamate; D-Penicillamine, N-Boc, S-Trt protected; Boc-D-3,3-Dimethylcysteine(Trt)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Pen(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant industry standards, and custom purity grades or specific impurity limits can be accommodated to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.