Description

6-Benzyl-5,6,7,8-Tetrahydro-1H-Pyrido[4,3-D]Pyrimidine-2,4-Dione is a high-purity, heterocyclic organic compound serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in its role as a sophisticated building block for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. This product is essential for research and development chemists, process development scientists, and manufacturers in the pharmaceutical and biotechnology industries seeking to innovate in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs, leveraging its fused pyrimidine-dione core structure.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and kilogram-to-ton scale production of target molecules under cGMP conditions.
• Biochemical Tool Compound: Potential use in biochemical assays as a reference standard or probe for studying specific enzymatic or receptor interactions.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for the production of proprietary compounds for clinical trial materials (CTM) and commercial supply.

Basic Information

Product Name	6-Benzyl-5,6,7,8-Tetrahydro-1H-Pyrido[4,3-D]Pyrimidine-2,4-Dione
CAS No.	135481-57-1
Molecular Formula	C₁₄H₁₅N₃O₂
Molecular Weight	257.29 g/mol
Synonyms	6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4(3H,8aH)-dione; 1H-Pyrido[4,3-d]pyrimidine-2,4-dione, 5,6,7,8-tetrahydro-6-(phenylmethyl)-; 6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione; 6-Benzyl-1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our production of 6-Benzyl-5,6,7,8-Tetrahydro-1H-Pyrido[4,3-D]Pyrimidine-2,4-Dione adheres to stringent quality management systems, ensuring batch-to-batch consistency and traceability. All materials undergo comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment. We support development under quality agreements and can supply material suitable for use in cGMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.