Description

n-Biotinyl-12-Aminododecanoic Acid is a high-purity, synthetic biotin derivative featuring a 12-carbon linker. This compound is engineered to provide a stable, long-chain spacer arm for the conjugation of biotin to various biomolecules, enhancing binding studies and detection systems. It is an essential intermediate for researchers and manufacturers in the life sciences sector, particularly in the development of diagnostic assays, targeted drug delivery systems, and advanced bioconjugation platforms.

Application

• Bioconjugation Reagent: Acts as a critical linker for attaching biotin to antibodies, proteins, peptides, and oligonucleotides.
• Diagnostic Assay Development: Used in the synthesis of probes and reagents for ELISA, lateral flow tests, and other immunoassay formats.
• Avidin/Biotin Technology (ABT): Serves as a key component in streptavidin-biotin based amplification systems for microscopy, flow cytometry, and biosensors.
• Drug Delivery Systems: Employed in the design of biotinylated liposomes, nanoparticles, and antibody-drug conjugates (ADCs) for targeted therapy.
• Affinity Chromatography: Used to create biotinylated ligands for the purification of specific proteins or other biomolecules.
• Surface Functionalization: Facilitates the biotinylation of chips, beads, and other solid supports for microarray and capture applications.
• Research & Development: A vital tool in academic and industrial R&D for studying protein-protein interactions, cell labeling, and molecular recognition.

Basic Information

Product Name	n-Biotinyl-12-Aminododecanoic Acid
CAS No.	135447-73-3
Molecular Formula	C22H41N3O4S
Molecular Weight	443.65 g/mol
Synonyms	12-[(5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl)amino]dodecanoic Acid; Biotin-12-Aminododecanoic Acid; Biotin-XX; Biotin-LC-LC-NHS; Biotinylated 12-Aminododecanoic Acid; N-Biotinyl-1,12-Dodecanedioic Acid Monoamide; EZ-Link™ Biotin-LC-LC-NHS (similar); Long-Chain Biotin NHS Ester Precursor
EINECS	Contact for details

Quality Control

Our n-Biotinyl-12-Aminododecanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.