Description

Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic cyclic peptide with the CAS Registry Number 135432-37-0. This compound is a key molecular scaffold designed to mimic the Arg-Gly-Asp (RGD) sequence, a critical motif for cell adhesion and recognition. It is primarily utilized by researchers and manufacturers in the fields of biomedical research, pharmaceutical development, and advanced material science for studying integrin-mediated processes and developing targeted therapeutics.

Application

• Biomedical Research: As a potent integrin antagonist for studying cell adhesion, migration, and signaling pathways in cancer and angiogenesis research.
• Drug Discovery: Serving as a lead compound or a targeting moiety in the development of novel anti-thrombotic, anti-cancer, and anti-angiogenic therapeutics.
• Biomaterial Functionalization: Coating surfaces of medical devices, implants, and tissue engineering scaffolds to promote specific cellular interactions or improve biocompatibility.
• Diagnostic Development: Used in the design of imaging probes and biosensors for the detection of specific integrin expressions associated with diseases.
• Peptide Chemistry & Conjugation: Acting as a versatile building block for the synthesis of more complex peptide-based constructs and bioconjugates.

Basic Information

Product Name	Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)
CAS No.	135432-37-0
Molecular Formula	C23H36N10O9
Molecular Weight	620.60 g/mol
Synonyms	c(RGDfV); Cyclo(Arg-Gly-Asp-D-Phe-Val); Cyclo(RGDfV); Cilengitide intermediate; RGD cyclic pentapeptide; Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro-OH); Cyclo(Gly-Arg-Gly-Asp-Ser-Pro); Integrin antagonist peptide
EINECS	Contact for details

Quality Control

Our Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed HPLC chromatograms and mass spectrometry data. Specifications are aligned with standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.